Science

Panx1: An upstream target in chronic pain

Panx1 channels sit at the origin of a self-sustaining neuroimmune loop that drives pain persistence. By blocking Panx1 early, the goal is to interrupt the cycle.

Block upstream. Interrupt the cycle.

The Panx1-Driven Cycle of Chronic Pain

Panx1 activation is an upstream event that initiates and sustains chronic pain.

1. Nerve Injury or Stress

Tissue injury or stress activates peripheral nerves and glia.

2. Panx1 Opens

Panx1 channels open at the cell membrane.

3. ATP Release

ATP acts as an extracellular danger signal.

4. Neuroimmune Amplification

Inflammatory signaling and sensitization are amplified.

5. Persistent Pain

The cycle sustains pain hypersensitivity.

Why Target Panx1?

Upstream inhibition addresses the root of the pain cycle, not just the symptoms.

Upstream Target

Acts near the origin of the pain cascade.

Interrupts the Cycle

Reduces neuroimmune amplification and sensitization.

Broad Therapeutic Potential

Relevant across multiple chronic pain conditions.

Disease-Biology Potential

Designed to address pain-maintaining biology.

Best-in-Class Opportunity

Blockers designed for potency, selectivity and development.